- Karaikal Port is connected by major roads to NH-67 at Nagapattinam which is about 10 km from the port.
- This link connects Karaikal port to central Tamil Nadu at Trichy.NH-45 which passes through Trichy connects Karaikal to northern hinterland right up till Chennai.
- NH-67 starting from Nagapattinam traverses Central Tamil Nadu in a near Straight line connecting the major industrial areas such as Thiruchirapalli, Karur and Coimbatore as well as onward linkages to other industrial areas such as Salem, Erode and Mettur.
- Karaikal is also connected all the way to Chennai through NH-45A which passes through Cuddalore. In addition to the national highways, a network of state hichways connects Karaikal to other industrial centre in Tamil Nadu.
